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The application of whole-genome tiling microarrays for studies of global gene expression is providing a more unbiased view of the transcriptional activity within genomes.

 


Selected Publications

 

Alonso, J.M., Stepanova, A.N., Leisse, T.J., Kim, C.J., Chen, H., Shinn, P., Stevenson, D.K., Zimmerman, J., Barajas, P., Cheuk, R., Gadrinab, C., Heller, C., Jeske, A., Koesema, E., Meyers, C.C., Parker, H., Prednis, L., Ansari, Y., Choy, N., Deen, H., Geralt, M., Hazari, N., Hom, E., Karnes, M., Mulholland, C., Ndubaku, R., Schmidt, I., Guzman, P., Aguilar-Henonin, L., Schmid, M., Weigel, D., Carter, D.E., Marchand, T., Risseeuw, E., Brogden, D., Zeko, A., Crosby, W.L., Berry, C.C. and Ecker. J.R., (2003) Genome-wide Insertional mutagenesis of Arabidopsis thaliana. Science, 301:653-657.

Yamada K, Lim J, Dale JM, Chen H, Shinn P, Palm CJ, Southwick AM, Wu HC, Kim C, Nguyen M, Pham P, Cheuk R, Karlin-Newmann G, Liu SX, Lam B, Sakano H, Wu T, Yu G, Miranda M, Quach HL, Tripp M, Chang CH, Lee JM, Toriumi M, Chan MM, Tang CC, Onodera CS, Deng JM, Akiyama K, Ansari Y, Arakawa T, Banh J, Banno F, Bowser L, Brooks S, Carninci P, Chao Q, Choy N, Enju A, Goldsmith AD, Gurjal M, Hansen NF, Hayashizaki Y, Johnson-Hopson C, Hsuan VW, Iida K, Karnes M, Khan S, Koesema E, Ishida J, Jiang PX, Jones T, Kawai J, Kamiya A, Meyers C, Nakajima M, Narusaka M, Seki M, Sakurai T, Satou M, Tamse R, Vaysberg M, Wallender EK, Wong C, Yamamura Y, Yuan S, Shinozaki K, Davis RW, Theologis A, and Ecker JR. (2003) Empirical analysis of transcriptional activity in the Arabidopsis genome, Science, 302:842-846.

Guo, H., and Ecker J.R. (2003) Plant Responses to Ethylene Gas Are Mediated by SCFEBF1/EBF2-dependent Proteolysis of EIN3 transcription factor. Cell 115: 667-677.

Wang, K. L., Yoshida, H., Lurin, C., and Ecker, J. R. (2004). Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein. Nature 428, 945-950.

Li, H., Johnson, P., Stepanova, A., Alonso, J. M., and Ecker, J. R. (2004). Convergence of signaling pathways in the control of differential cell growth in Arabidopsis. Dev Cell 7, 193-204.

Mockler TC, Chan S, Sundaresan A, Chen H, Jacobsen SE, Ecker JR. (2005) Applications of DNA tiling arrays for whole-genome analysis. Genomics. 85(1):1-15.

Alonso, J.M. and J.R. Ecker (2006) Moving forward in reverse: genetic technologies to enable genome-wide phenomic screens in Arabidopsis. Nat. Rev. Genet, 7:524-

Olmedo, G., G. Guo, B.D. Gregory, S.D. Nourizadeh, L. Aguilar-Henonin, H. Li, H. An, P. Guzman, and J.R. Ecker (2006) ETHYLENE-INSENSITIVE5 encodes a 5'→3' exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2. Proc Natl Acad Sci U S A, |. 103: 13286-13293

Zhang, X., Yazaki, J., Sundaresan, A. Cokus,S., Chan, S.W.-L., Chen, H., Henderson, I.R., Shinn, P., Pellegrini, M., Jacobsen, S.E., and Ecker, J.R. (2006) Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis, Cell, 126, 1189–1201

Clark, RM, Schweikert, G., Toomajian, C., Ossowski, S., Zeller, G., Shinn, P., Warthmann, N., Hu, T.T., Fu, G., Hinds. D.A. , Chen, H., Frazer, K.A., Huson, D.H., Schölkopf, B., Nordborg, M., Rätsch, G., Ecker. J. R., and Weigel, D. (2007) Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana, in revision

 

(Recent Publications-PubMed database)